| Date | Home | Away | Venue | Time |
|---|---|---|---|---|
| Fri, Apr 14 | Cell C Sharks | Benetton | Hollywoodbets Kings Park | 18:30 |
| Fri, Apr 14 | Glasgow Warriors | Scarlets | Scotstoun Stadium | 20:35 |
| Fri, Apr 14 | Ulster | Dragons RFC | Kingspan Stadium | 20:35 |
| Sat, Apr 15 | Emirates Lions | Leinster | Emirates Airline Park | 14:00 |
| Sat, Apr 15 | Vodacom Bulls | Zebre Parma | Loftus Versfeld Stadium | 16:05 |
| Sat, Apr 15 | DHL Stormers | Munster | DHL Stadium | 18:15 |
| Sat, Apr 15 | Connacht | Cardiff Rugby | The Sportsground | 20:35 |
| Sat, Apr 15 | Edinburgh Rugby | Ospreys | DAM Health Stadium | 20:35 |
| Fri, Apr 21 | DHL Stormers | Benetton | Danie Craven Stadium | 18:30 |
| Fri, Apr 21 | Ulster | Edinburgh Rugby | Kingspan Stadium | 20:35 |
| Sat, Apr 22 | Emirates Lions | Zebre Parma | Emirates Airline Park | 14:00 |
| Sat, Apr 22 | Dragons RFC | Scarlets | Rodney Parade | 16:00 |
| Sat, Apr 22 | Vodacom Bulls | Leinster | Loftus Versfeld Stadium | 16:05 |
| Sat, Apr 22 | Ospreys | Cardiff Rugby | Swansea.com Stadium | 18:15 |
| Sat, Apr 22 | Cell C Sharks | Munster | Hollywoodbets Kings Park | 18:15 |
| Sat, Apr 22 | Glasgow Warriors | Connacht | Scotstoun Stadium | 20:35 |
| May 5 | ||||
| May 6 | ||||
| May 6 | ||||
| May 6 | ||||
| May 12 or 13 | ||||
| May 12 or 13 | ||||
| May 27 |
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